Review of Antihypertensive Activity of Purslane (Portulaca oleracea L.)

Rizqi Nur Azizah; Bayu Putra; Asriani Suhaenah; Fadlina Chany Saputri; Aktsar Roskiana Ahmad; Abdul Malik

doi:10.70392/jpns.v2i2.5461

Authors

Rizqi Nur Azizah Fakultas Farmasi, Universitas Muslim Indonesia, Makassar Author
Bayu Putra Fakultas Farmasi, Universitas Muslim Indonesia, Makassar Author
Asriani Suhaenah Fakultas Farmasi, Universitas Muslim Indonesia, Makassar Author
Fadlina Chany Saputri Universitas Indonesia Author
Aktsar Roskiana Ahmad Universitas Muslim Indonesia Author
Abdul Malik Universitas Muslim Indonesia Author

DOI:

https://doi.org/10.70392/jpns.v2i2.5461

Keywords:

Antihypertensive, Blood pressure, Portulaca oleracea L, Purslane

Abstract

Hypertension is a chronic disease in which blood pressure in the arteries increases. Hypertension is a health problem that has a risk of causing other diseases such as coronary heart disease, kidney failure, nerve dysfunction and stroke. Plants such as purslane (Portulaca oleracea L.) are one of the plants that have benefits in treating disease. The purpose of the review article is to determine the potential of Portulaca oleracea L. as an anti-hypertensive. This research is a Review Journal. The subject of this review is national and international articles indexed nationally and internationally in the last 10 years which discuss the antihypertensive ability of Portulaca oleracea L. by classifying them based on the type of study and test model used in-vivo, the potential of the plant in lowering blood pressure, mechanism of action in treating hypertension, and specific chemical constituents responsible for anti-hypertensive activity. Based on the results of studies conducted on several journal articles, it can be concluded that Portulaca oleracea L. : 1. exhibits promising antihypertensive properties through various mechanisms, including vasodilation, reduction of heart rate, and improvement of endothelial function; 2. Clinical trials and comparative studies indicate that it can significantly reduce systolic blood pressure, making it a potential natural adjunct in managing hypertension; 3. exhibits multiple mechanisms that can help manage hypertension, primarily through its antioxidant, anti-inflammatory, and lipid-regulating properties, 4. contains several bioactive compounds that contribute to its antihypertensive effects such as Asperglaucide (ASP), Oleracein E and Oleracein L, Omega-3 Fatty Acids, Quercetin, and Rutin.

References

WHO. Global Report on Hypertension: the race against a silent Killer. 2023. https://who.int.

Susanti, S., Bujawati, E., Sadarang, R.A.I., Ihwana, D. Hubungan Self Efficacy dengan manajemen diri penderita hipertensi di Puskesmas Kassi-Kassi Kota Makassar Tahun 2022. Jurnal Kesmas Jambi 2022, 6 (2), 48–58. https://doi.org/10.22437/JKMJ.V6I2.20540.

Kementrian Kesehatan RI. Riset Kesehatan Dasar. Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan RI: Jakarta, 2013.

Irsal, R.A.P., Rosyidah, R.A. Kurnia, M.R.A., Aisyah, S.I. Nurcholis, W. Potensi senyawa antioksidan dari tanaman Krokot (Portulaca grandiflora): Narrative review. Jurnal Farmamedika (Pharmamedika Journal) 2023, 8 (1), 25–35. https://doi.org/10.47219/ATH.V8I1.192.

Zhou, Y.X., Xin, H.L., Rahman, K., Wang, S.J., Peng, C., Zhang, H. Portulaca oleracea L.: A review of phytochemistry and pharmacological effects. Biomed Res Int 2015, 2015. https://doi.org/10.1155/2015/925631.

Syed, S., Fatima, N., Kabeer, G. Portulaca oleracea L.: A mini review on phytochemistry and pharmacology. International Journal of Biology and Biotechnology 2016, 13 (4), 637–641.

Jayanti, A.S.D., Sitasiwi, A.J., Isdadiyanto, S. Effect of Purslane (Portulaca oleracea L.) ethanol extract in alloxan-induced hyperglycemic rats (Rattus novergicus L.) blood glucose levels. Jurnal Sain Veteriner 2022, 40 (3), 237–243. https://doi.org/10.22146/JSV.61937.

Yuniastri, R., Hanafi, I., Sumitro, E.A. Potensi antioksidan pada Krokot (Portulaca oleracea) sebagai pangan fungsional. Jurnal Keteknikan Pertanian Tropis dan Biosistem 2020, 8 (3), 284–290. https://doi.org/10.21776/UB.JKPTB.2020.008.03.10.

Andayani, D., Suprihartini, E., Astuti, M. Efek antiinflamasi ekstrak etanol Krokot (Portulaca oleracea L.) pada udema tikus yang di induksi karagenin. JPSCR: Journal of Pharmaceutical Science and Clinical Research 2018, 3 (1), 43. https://doi.org/10.20961/jpscr.v3i1.15108.

Azizah, R.N., Emelda, A., Asmaliani, I. Potensi tanaman Krokot (Portulaca oleraceae) sebagai bahan obat antiobesitas. Yayasan Pendidikan Cendekia Muslim: Solok, 2023.

Nabilah, L., Dewanti, F.D., Koentjoro, Y., Tarigan, P.L. Respon macam pupuk terhadap pertumbuhan, hasil dan omega-3 pada tanaman Krokot (Portulaca oleracea L.). Agro Bali: Agricultural Journal 2023, 6(3), 840–851. https://doi.org/10.37637/AB.V6I3.1290.

Husein, S.G., Sundalian, M., Husna, N. Review: Analisis komponen senyawa kimia Krokot (Portulaca oleraceae L. dan Portulaca grandiflora Hook). Jurnal Sains dan Kesehatan 2021, 3 (2), 317–327. https://doi.org/10.25026/JSK.V3I2.278.

Aslan, M., Basralı, F., Ülker, P., Barut, Z., Yılmaz, Ç., Çeker, T., Özen, N., Öztüzün, A., Elpek, Ö. Effects of aurantiamide on a rat model of renovascular arterial hypertension. Pflugers Arch 2023, 475 (10), 1177–1192. https://doi.org/10.1007/S00424-023-02850-8.

Miao, L., Zhou, C., Zhang, H., Cheong, M.S., Tan, Y., Wang, Y., Zhang, X., Yu, H., Cheang, W.S. Portulaca oleracea L. (Purslane) extract protects endothelial function by reducing endoplasmic reticulum stress and oxidative stress through AMPK activation in diabetic obese mice. Antioxidants 2023, 12(12), 2132. https://doi.org/10.3390/ANTIOX12122132.

Wainstein, J., Landau, Z., Dayan, Y.B., Jakubowicz, D., Grothe, T., Perrinjaquet-Moccetti, T., Boaz, M. Purslane Extract and Glucose Homeostasis in Adults with Type 2 Diabetes: A Double-Blind, Placebo-Controlled Clinical Trial of Efficacy and Safety. Journal of Medicinal Food 2016, 19 (2), 133–140. https://doi.org/10.1089/JMF.2015.0090.

Sutjiatmo, A.B., Azhari, F., Vikasari, S.N. Vasodilatation effects of Portulaca oleracea L. ethanol extract on animal models. IOP Conf Ser Earth Environ Sci 2022, 1104 (1), 012015. https://doi.org/10.1088/1755-1315/1104/1/012015.

Jalali, J., Ghasemzadeh Rahbardar, M. Ameliorative effects of Portulaca oleracea L. (Purslane) on the metabolic syndrome: A review. J Ethnopharmacol 2022, 299. https://doi.org/10.1016/J.JEP.2022.115672.

Esmaillzadeh, A., Zakizadeh, E., Faghihimani, E., Gohari, M., Jazayeri, S. The effect of Purslane seeds on glycemic status and lipid profiles of persons with type 2 diabetes: A randomized controlled cross-over clinical trial. J Res Med Sci, 2015, 20 (1), 47.

Kim, K.-H., Park, E.-J., Jang, H.-J., Lee, S.-J., Park, C. S., Yun, B.-S., Lee, S.W., Rho, M.-C. 1-Carbomethoxy-β-carboline, derived from Portulaca oleracea L., Ameliorates LPS-mediated inflammatory response associated with MAPK signaling and nuclear translocation of NF-ΚB. Molecules 2019, 24 (22), 4042. https://doi.org/10.3390/molecules24224042.

Askari, V.R., Rezaee, S.A., Abnous, K., Iranshahi, M., Boskabady, M.H. The influence of hydro-ethanolic extract of Portulaca oleracea L. on Th1/Th2 balance in isolated human lymphocytes. J Ethnopharmacol 2016, 194, 1112–1121. https://doi.org/10.1016/J.JEP.2016.10.082.

Safaeian, L., Baniahmad, B., Esfandiari, Z., Alavi, S.A. Portulaca oleracea seeds extract does not prevent dexamethasone-induced hypertension in rats. Journal of Herbmed Pharmacology 2017, 7 (1), 8–12. https://doi.org/10.15171/jhp.2018.02.

Roozi, H., Bojar, M.N.A., Eidi, V., Ali, K.N.R. Effects of oleracein E and oleracein L from Portulaca oleracea on cell survival, antioxidant and antidiabetic efficacy on beta-TC-6 pancreatic cell line. Indian J Pharm Sci 2019, 81 (4), 681–689. https://doi.org/10.36468/PHARMACEUTICAL-SCIENCES.559.

Pakdel, R., Vatanchian, M., Niazmand, S., Beheshti, F., Rahimi, M., Aghaee, A., Hadjzadeh, M.A.R. Comparing the effects of Portulaca oleracea seed hydro-alcoholic extract, valsartan, and vitamin E on hemodynamic changes, oxidative stress parameters and cardiac hypertrophy in thyrotoxic rats. Drug Chem Toxicol 2022, 45 (1), 14–21. https://doi.org/10.1080/01480545.2019.1651330.

Karamalakova, Y., Petkova-Parlapanska, K., Hinkov, I., Vetskov, N., Georgieva, E., Nikolova, G. The effect of radiation preservation on macromolecule content, antimicrobial activity and radical - scavenging potential of Portulaca oleracea L. leaves extract. Journal of Chemical Technology and Metallurgy 2024, 59(2), 243–249. https://doi.org/10.59957/JCTM.V59.I2.2024.2.