In Silico Study of Phytochemical Compound from Daun Kluwih  (Artocarpus camansi) as an Antidiabetic Targeting Aldose Reductase

Dinar Umaimah Radani; Ignasia Anindya Pintagratia; Anindya Nursanti Syaiful; Fahri Renaldi; Fachrizal Dwi Kautsar; Dhania Novitasari

doi:10.70392/jpns.v3i1.49

Authors

Dinar Umaimah Radani Padjadjaran University Author
Ignasia Anindya Pintagratia Padjadjaran University Author
Anindya Nursanti Syaiful Padjadjaran University Author
Fahri Renaldi Padjadjaran University Author
Fachrizal Dwi Kautsar Padjadjaran University Author
Dhania Novitasari Faculty of Pharmacy, Universitas Padjadjaran Author

DOI:

https://doi.org/10.70392/jpns.v3i1.49

Keywords:

Aldose Reductase, Artocarpus camansi, Diabetes Mellitus

Abstract

Diabetes Mellitus (DM) is a disease characterized by increased blood glucose levels. The most common type of diabetes is type 2 diabetes mellitus. Aldose Reductase is an enzyme that works in the polyol pathway. The polyol pathway is the pathway where glucose is metabolized by aldose reductase into sorbitol. The end result of this polyol pathway will accumulate in the tissue so that there is a disruption of the osmolarity of the basal membrane which can cause complications of diabetes mellitus. Therefore, the activity of the aldose reductase enzyme must be inhibited, one of which is using chemical compounds so that complications such as cataracts do not occur. Tests conducted in this study include Lipinski's RO5, ADMETox, pharmacophore screening, and molecular docking. From the test results, it was found that the most potential compound in treating Diabetes Mellitus is Cycloartenol Acetate.

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