Tyrosinase Inhibitory Activity of The Extracts from Garcinia lateriflora Blume var. Javanica Boerl, Garcinia fruticosa Lauterb, and Garcinia xanthochymus
DOI:
https://doi.org/10.70392/drty6950Keywords:
Tyrosinase inhibitory, Garcinia lateriflora Blume var. javanica Boerl, Garcinia fruticose Lauterb, Garcinia xanthocymusAbstract
Tyrosinase overexpression in humans increases melanin production in the skin, which may have hyperpigmentation-causing effects. In this study, various extracts from the Garcinia lateriflora Blume var. Javanica Boerl, Garcinia fruticosa Lauterb, and Garcinia xanthochymus plants were tested for their ability to inhibit the tyrosinase enzyme. The results showed that the G. fruticosa Lauterb stem bark hexane extract had the highest activity followed succesively by the G. lateriflora Blume var javanica Boerl leaf methanol extract, G xanthochymus mesocarp hexane extract, G. xanthochymus mesocarp methanol extract. The results show that the G. fruticosa Lauterb stem bark hexane extract has the highest tyrosinase inhibitory activity (45.61 ± 1.58%) among the four extracts and the tyrosinase inhibitory activity of kojic acid (65.07 0.86%).
References
Cui, Hong Xin, Fang Fang Duan, Shan Shan Jia, Fang Rong Cheng, and Ke Yuan. 2018. “Antioxidant and Tyrosinase Inhibitory Activities of Seed Oils from Torreya Grandis Fort. Ex Lindl.” BioMed Research International 2018. doi: 10.1155/2018/5314320.
Yamaguchi, Yuji, Michaela Brenner, and Vincent J. Hearing. 2007. “The Regulation of Skin Pigmentation.” Journal of Biological Chemistry 282(38):27557–61. doi: 10.1074/jbc.R700026200.
Peng, Li-Hua, Shuai Liu, Shen-Yao Xu, Lei Chen, Ying-Hui Shan, Wei Wei, Wen-Quan Liang, and Jian-Qing Gao. 2013. “Inhibitory Effects of Salidroside and Paeonol on Tyrosinase Activity and Melanin Synthesis in Mouse B16F10 Melanoma Cells and Ultraviolet B-Induced Pigmentation in Guinea Pig Skin.” Phytomedicine 20(12):1082–87. doi: https://doi.org/10.1016/j.phymed.2013.04.015.
Wang, Guey-Horng, Chih-Yu Chen, Chia-Pei Lin, Chun-Ling Huang, Chia-hui Lin, Chiu-Yu Cheng, and Ying-Chien Chung. 2016. “Tyrosinase Inhibitory and Antioxidant Activities of Three Bifidobacterium Bifidum-Fermented Herb Extracts.” Industrial Crops and Products 89:376–82. doi: https://doi.org/10.1016/j.indcrop.2016.05.037.
Saqib, Fatima, Khalid Hussain Janbaz, and Maryam Khan Sherwani. 2015. “In Vitro Inhibitory Potential of Methanolic Extract of Celosia Argentea Var. Cristata on Tyrosinase, Acetylcholinesterase and Butyrylcholinesterase Enzymes.” Bangladesh Journal of Pharmacology 10(2):449–54. doi: 10.3329/bjp.v10i2.22880.
Lin, Yin-Shiou, Sheng-Hsuan Chen, Wei-Jan Huang, Chao-Hsiang Chen, Mei-Yin Chien, Shyr-Yi Lin, and Wen-Chi Hou. 2012. “Effects of Nicotinic Acid Derivatives on Tyrosinase Inhibitory and Antioxidant Activities.” Food Chemistry 132(4):2074–80. doi: https://doi.org/10.1016/j.foodchem.2011.12.052.
Ortonne, J. P. 2012. “Normal and Abnormal Skin Color.” Annales de Dermatologie et de Vénéréologie 139 Suppl:S125–29. doi: 10.1016/S0151-9638(12)70123-0.
Ambarwati, Neneng Siti Silfi, Islamudin Ahmad, Berna Elya, Amarila Malik, and Muhamad Hanafi. 2017. “Pharmacognostic and Antimicrobial Studies of Garcinia Latissima Miq. Leaves (Clusiaceae).” Pharmacognosy Journal 9(4):493–98. doi: 10.5530/pj.2017.4.80.
Ambarwati, Neneng Siti Silfi, Berna Elya, Amarila Malik, Muhammad Hanafi, and Muhamad Sharul Nizam Awang. 2022. “Isolation, Identification, and Antibacterial of Amentoflavone From Garcinia Latissima Miq. Leaves.” International Journal of Applied Pharmaceutics 14(Special Issue 3):67–73. doi: 10.22159/ijap.2022.v14s3.13.
Rosmalena, Nabilla Aretharify Putri, Fatmawaty Yazid, Neneng Siti Silfi Ambarwati, Hanita Omar, and Islamudin Ahmad. 2022. “Phytochemical, in Vitro Radical Scavenging and in Vivo Oxidative Stress Analysis of Peppermint (Mentha Piperita L.) Leaves Extract.” Journal of Advanced Pharmaceutical Technology and Research 13(2):133–37. doi: 10.4103/japtr.japtr_16_22.
Ambarwati, Neneng Siti Silfi, Berna Elya, Yesi Desmiaty, Dwi Atmanto, and Islamudin Ahmad. 2021. “Tyrosinase Inhibitory Activity of Garcinia Xanthochymus Fruit Pericarp Extract.” Pp. 1–4 in AIP Conference Proceedings. Vol. 2331.
Wang, Yuxi, Jinghui Jia, Qi Wang, Yulian Wei, and Haisheng Yuan. 2023. “Secondary Metabolites from the Cultures of Medicinal Mushroom Vanderbylia Robiniophila and Their Tyrosinase Inhibitory Activities.” Journal of Fungi 9(7). doi: 10.3390/jof9070702.
Furi, Mustika, Ainun Alfatma, Rahma Dona, Armon Fernando, Fina Aryani, Rahayu Utami, Septi Muharni, Husnawati, Wira Noviana Suhery, and Melzi Octaviani. 2022. “UJI INHIBITOR ENZIM TIROSINASE EKSTRAK DAN FRAKSI DAUN KEDABU (Sonneratia Ovata Backer) SECARA IN-VITRO.” Jurnal Ilmiah Manuntung 8(2):201–14. doi: 10.51352/jim.v8i2.529.
Neagu, Elena, Gabriel Lucian Radu, Camelia Albu, and Gabriela Paun. 2018. “Antioxidant Activity, Acetylcholinesterase and Tyrosinase Inhibitory Potential of Pulmonaria Officinalis and Centarium Umbellatum Extracts.” Saudi Journal of Biological Sciences 25(3):578–85. doi: 10.1016/j.sjbs.2016.02.016.
Biswas, Rajarshi, Pulok K. Mukherjee, Manoj Kumar Dalai, Prasanta Kumar Mandal, and Mrinmoy Nag. 2015. “Tyrosinase Inhibitory Potential of Purpurin in Rubia Cordifolia-A Bioactivity Guided Approach.” Industrial Crops and Products 74:319–26. doi: 10.1016/j.indcrop.2015.04.066.
Chang, Te Sheng. 2009. “An Updated Review of Tyrosinase Inhibitors.” International Journal of Molecular Sciences 10(6):2440–75. doi: 10.3390/ijms10062440.
Varga, János, J. C. Frisvad, and R. A. Samson. 2007. “Polyphasic Taxonomy of Aspergillus Section Candidi Based on Molecular, Morphological and Physiological Data.” Studies in Mycology 59:75–88. doi: 10.3114/sim.2007.59.10.
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